Multiple Sclerosis

Multiple sclerosis is a disorder of the brain and spinal cord. It can cause various symptoms. In most cases, episodes of symptoms come and go at first for several years. In time, some symptoms can become permanent and can cause disability. Although there is no cure for multiple sclerosis, various medicines and therapies may reduce the number of flare-ups and can help to ease symptoms and disabilities. MS is a disease where patches of inflammation occur in parts of the brain and/or spinal cord. This can cause damage to parts of the brain and lead to various symptoms (described below)

Many thousands of nerve fibres transmit tiny electrical messages (impulses) between different parts of the brain and spinal cord. Each nerve fibre in the brain and spinal cord is surrounded by a protective sheath made from a substance called myelin. The myelin sheath acts like the insulation around an electrical wire. It is needed for the electrical impulses to travel correctly along the nerve fiber.

Nerves are made up from many nerve fibres. Nerves come out of the brain and spinal cord and take messages to and from muscles, the skin, body organs and tissues.

MS is thought to be an autoimmune disease. This means that cells of the immune system, which normally attack germs (bacteria, viruses, etc), attack part of the body. When the disease is active, parts of the immune system, mainly cells called T cells, attack the myelin sheath which surrounds the nerve fibres in the brain and spinal cord. This leads to small patches of inflammation.

Something may trigger the immune system to act in this way. One theory is that a virus or another factor in the environment triggers the immune system in some people with a certain genetic makeup. Your genetic makeup is the material inherited from your parents which controls various aspects of your body.

The inflammation around the myelin sheath stops the affected nerve fibres from working properly and symptoms develop. When the inflammation clears, the myelin sheath may heal and repair and nerve fibres start to work again. However, the inflammation, or repeated bouts of inflammation, can leave a small scar (sclerosis) which can permanently damage nerve fibres. In a typical person with MS, many (multiple) small areas of scarring develop in the brain and spinal cord. These scars may also be called plaques.